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The Best Luxury Boutique Hotels in West Loop in 2026

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Welcome to our choices for this year’s best boutique hotels in Chicago’s West Loop!

Originally a humble home to wholesale food markets and industrial spaces, West Loop has been transformed.

You’ll find little trace of old school grit – modern West Loop has some of Chicago’s trendiest entertainment, boutique shopping and, most particularly, dining spots.

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Chicago

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The Publishing House Hotel

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Number of Rooms: 11
Guide Price: Between $200 & $300 per Night
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Address: 108 North May Street
West Loop
Chicago
Illinois
60607
Compare it with others in: Adults Only Boutique Hotels and Luxury Boutique Hotels
Built for book lovers, this West Loop gem is a nice mix of homely bed and breakfast, and hip Chicago boutique hotel. We love a mom-and-pop, show-us-pictures-of-your-grandchildren BnB as much as the next person (maybe more?) but the Publishing House builds on the concept. It’s literary themed. Built in an old publishing house, each room is dedicated to a major Chicago literary figure. The Dybek Room is named after Stuart Dybek, who wrote The Coast of Chicago, for example, while the Audrey of The Audrey Room is Audrey Niffenegger, of… > Read Our Full Review