2 Best, Genuine Boutique Hotels in Downtown in 2026

There are many great boutique hotels in Marriott’s Autograph Collection, a portfolio of upscale, independent affiliates. This Downtown offering is definitely one of them: a plush, tasteful and well-situated property from which to enjoy St. Louis. Hotel Saint Louis provides more than enough comfort for those for whom boutique hotel means luxury hotel, and it couldn’t be closer to most of the main attractions.   What are the rooms like? Room count: 142 rooms, eight different types including Corner King Rooms and Penthouse. Beds: King or two Queen beds; suites… > Read Our Full Review

21c, a midwestern chain of contemporary-art-meets-hotel, has its Saint Louis boutique offering parked on the western side of Downtown, a gorgeous location for a gorgeous concept. As a museum, it’s certainly unconventional, which is a main strength. The rotating selection of artwork bleeds into common spaces that are so artfully decorated on their own it’s difficult to tell where the show stops. The result is a comfortable, friendly, and uniquely beautiful hotel. While some 21c hotels are a little large for that intimate boutique feeling, this stunner of a building,… > Read Our Full Review